Anti-Angiogenesis Strategies in Cancer Therapies by Shaker Mousa, Paul Davis

By Shaker Mousa, Paul Davis

Anti-angiogenesis concepts in melanoma Therapeutics presents a close examine the present prestige and destiny instructions within the discovery and improvement of novel anti-angiogenesis techniques in oncology. This e-book highlights the several mechanisms concerned about the modulation of angiogenesis, together with irritation, thrombosis, and microRNA, and indicates how nanotechnology can extra improve the opportunity of latest and new anti-angiogenesis approaches.

Written for scientists, researchers, oncologists, hematologists, and professors and scholars within the box, this accomplished ebook covers all facets of anti-angiogenesis ideas and their differences.
Key Features

Covers vital preclinical types and scientific trials within the discovery and improvement of novel anti-angiogenesis agents
experiences FDA-approved anti-angiogenesis agents
Illustrates the worth of nanotechnology in enhancing the software of anti-angiogenesis agents
deals perception into the improvement of novel anti-angiogenesis brokers and destiny course during this area

Readership

Pharmaceutical scientists and researchers in pharmaceutical and biotechnology businesses, oncologists, hematologists, graduate and post-graduate scholars in those parts and educational faculty

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Lenalidomide restrains motility and overangiogenic potential of bone marrow endothelial cells in patients with active multiple myeloma. Clin Cancer Res 2011;17(7):1935–46. [20] Chen C, Reece DE, Siegel D, Niesvizky R, Boccia RV, Stadtmauer EA, Abonour R, Richardson P, Matous J, Kumar S, Bahlis NJ, Alsina M,Vescio R, Coutre SE, Pietronigro D, Knight RD, Zeldis JB, RajkumarV. ­Expanded safety experience with lenalidomide plus dexamethasone in relapsed or refractory multiple myeloma. Br J Haematol 2009;146(2):164–70.

Several clinical studies were led in 2006 by the Food and Drug Administration (FDA) for the approval of the drug in ­patients with relapsed/refractory MM and this led to response rates as high as 65% [13–15]. Lenalidomide is an analog of thalidomide with anti-angiogenic proprieties. It inhibits VEGF-induced PI3-K-Akt pathway signaling and hypoxia inducible factor 1 alpha (HIF-1α) expression [16], exerts anti-tumor necrosis factor alpha (TNF-α) activity, modulates the immune response stimulating T-cells’ and NK-cells’ activities, induces apoptosis of tumor cells and decreases the binding of MM cells to bone marrow stromal components [10,11,17,18].

11] Mitsiades N, Mitsiades CS, Poulaki V, Chauhan D, Richardson PG, Hideshima T, Munshi NC, Treon SP, Anderson KC. Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implications. Blood 2002;99(12):4525–30. [12] Singhal S, Mehta J, Desikan R, Ayers D, Roberson P, Eddlemon P, Munshi N, Anaissie E, Wilson C, Dhodapkar M, Zeddis J, Barlogie B. Antitumor activity of thalidomide in refractory multiple myeloma. N Engl J Med 1999;341(21):1565–71.

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