By Edward B Stelow MD, Stacey Mills
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Additional resources for Biopsy Interpretation of the Upper Aerodigestive Tract and Ear
4). Dyskeratotic cells are more prominent than in mild dysplasia. The atypia may also be more pronounced; however, if it is severe, such lesions may be categorized as severe dysplasia. Severe Dysplasia These lesions are defined as showing architectural disturbances that extend to more than two-thirds of the thickness of the squamous epithelium, with marked cytologic atypia (Fig. 5, e-Fig. 3). Dyskeratotic cells are often numerous. It should be noted, however, that even severe dysplasia in the head and neck, particularly when related to smoking, typically maintains some surface maturation and keratinization.
The exact role that EBV plays in the 46 –––––– biopsy interpretation of the upper aerodigestive tract and ear evelopment of these tumors is unclear. EBV-associated tumors are disd cussed in more detail in Chapter 5. 25-28 Our understanding of the role that HPV plays in the development of these tumors has progressed quickly over the past decade. We know that these tumors are almost always located in the oropharynx (the palatine and lingual tonsils), although the tumors rarely can occur throughout the entire tract.
Cancer Res. 2001;61:2371-2375. 29. Choi HR, Tucker SA, Huang Z, et al. Differential expressions of cyclin-dependent kinase inhibitors (p27 and p21) and their relation to p53 and Ki-67 in oral squamous tumorigenesis. Int J Oncol. 2003;22:409-414. 30. Farrar M, Sandison A, Peston D, Gailani M. Immunocytochemical analysis of AE1/ AE3, CK 14, Ki-67 and p53 expression in benign, premalignant and malignant oral tissue to establish putative markers for progression of oral carcinoma. Br J Biomed Sci. 2004;61:117-124.