Biopsy Interpretation of the Uterine Cervix and Corpus by Anais Malpica MD, Elizabeth D. Euscher MD

By Anais Malpica MD, Elizabeth D. Euscher MD

Part of the great Biopsy Interpretation sequence, the second one version of Biopsy Interpretation of the Uterine Cervix and Corpus presents an easy-to-follow, sensible method of basic histology, non-neoplastic stipulations, and neoplasia of the cervix and uterine physique. concentrating on the commonest biopsies, this updated bench reference emphasizes morphologic beneficial properties and immunohistochemistry within the diagnostic fabric, with shut cognizance paid to differential prognosis, together with benign mimics of tumors.

Key Features

  • Stay modern with what’s new in gynecologic pathology with an all-new bankruptcy on metastatic tumors, plus up to date references and terminology throughout.
  • Focus on differential analysis and often encountered pitfalls of the most typical entities saw within the cervix, endometrium, and myometrium.
  • Clearly visualize the specimens you’re prone to see with 1000's of high quality pictures, either within the textual content and online.
  • Get updated counsel on ancillary assessments corresponding to in situ hybridization for HPV and molecular reports for microsatellite instability review and molar pregnancy.
  • Test your wisdom online with over 50 questions perfect for self-assessment.
Now with the print version, benefit from the bundled interactive e-book version, providing capsule, cellphone, or on-line entry to:
  • 50 questions for assessment and self-assessment, plus over 1,000 extra full-color images on hand purely online.
  • Complete content material with better navigation
  • Powerful seek instruments and shrewdpermanent navigation cross-links that pull effects from content material within the e-book, your notes, or even the web
  • Cross-linked pages, references, and more for simple navigation
  • Highlighting tool for less complicated reference of key content material in the course of the text
  • Ability to take and percentage notes with neighbors and colleagues
  • Quick reference tabbing to save lots of your favourite content material for destiny use

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Additional resources for Biopsy Interpretation of the Uterine Cervix and Corpus

Example text

In these cases, p16 may be helpful because it is negative in cases of reactive changes (8). 8 Reactive atypia of the squamous epithelium—enlarged nuclei and clearing of the cytoplasm with inflammatory cells in the epithelium. RADIATION-INDUCED ATYPIA Radiation-induced atypia can be identified immediately or years after radiotherapy. Acute changes include cytomegaly of the squamous epithelium due to nuclear and cytoplasmic swelling, as well as cytoplasmic vacuolization, prominent nucleoli, and erosion (Fig.

Uneven spacing of the nuclei giving the impression of “clones,” as seen in cartilage) and the previously mentioned nuclear changes in scattered nuclei (Fig. 10, e-Figs. 36). As stated earlier, LSILs can show mild to moderate alterations in the lower third of the epithelium. These alterations include the loss of the picket-fence arrangement of the basal cells and mild to moderate cytologic atypia consisting of nuclear enlargement and variation in the nuclear shape and size. Alterations in the chromatin pattern, as well as mitotic figures, may be present.

Moving upward in the endocervical canal, subcolumnar reserve cells maintain expression of p63 and cytokeratins 5 and 7 but the percentage and intensity of staining for bcl-2 and cytokeratin 17 diminishes (10). Neuroendocrine cells have also been described (2). The endocervical epithelium lines not only the surface of the endocervical canal, but also the endocervical clefts and glands that are contained within the cervical stroma (Fig. 6, e-Fig. 9), usually up to 5 mm in depth, and on rare occasions up to 1 cm (11).

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