Bone Marrow-Derived Progenitors by J. -P. Lévesque, I. G. Winkler, S. R. Larsen, J. E. J. Rasko

By J. -P. Lévesque, I. G. Winkler, S. R. Larsen, J. E. J. Rasko (auth.), Katalin Kauser MD, PhD, DSc, Andreas-Michael Zeiher MD (eds.)

There is pleasure generated virtually day-by-day concerning the attainable makes use of of stem cells to regard human disease.

The skill of stem cells to obtain diverse wanted phenotypes has opened the door for a brand new self-discipline: regenerative medication. a lot of the curiosity for this goal is generated through embryonic stem cells, yet their use continues to be arguable for ethical purposes in addition to scientifically. much less debatable and available are the grownup bone marrow-derived progenitors together with hematopoietic stem cells, endothelial progenitors and mesenchymal stem cells.

The formidable objective of this quantity is to supply a entire assessment of the presently on hand details regarding the healing application of grownup bone marrow-derived cells. each one bankruptcy has been written through an comprehensive specialist within the box, making this a highly beneficial source for someone searching for an up to the moment evaluate of present perform in grownup bone marrow-derived phone therapy.

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2 EDNO Dependent Bone Marrow Cell Mobilization . 3 EDNO-Independent Bone Marrow Cell Mobilization 4 Summary . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37 38 40 41 41 Abstract Mobilization and recruitment of bone marrow-derived progenitor cells (BMDPCs) play an important role in postischemic tissue repair. Patients with coronary artery disease (CAD) or peripheral vascular disease (PVD) exhibit endothelial dysfunction, and as a result are likely to have a reduced number of progenitor cells mobilized in their peripheral circulation following ischemic injury.

Science 275:964–966 Asahara T, Takahashi T, Masuda H, et al (1999) VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells. EMBO J 18:3964–3972 Avecilla ST, Hattori K, Heissig B, et al (2004) Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis. Nat Med 10:64–71 Balsam LB, Wagers AJ, Christensen JL, et al (2004) Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium.

Therefore, although not expressed in hematopoietic cells, Nos3 regulates the homeostasis of the BM stroma that regulates the fate of both EPCs and HPCs. Therefore, from these studies, it is clear that a population of still not well defined EPCs is mobilized from the BM into the blood, and that this mobi- Mobilization of Bone Marrow-Derived Progenitors 23 Fig. 3 Model of EPC mobilization. Ischemic tissues release TPO and soluble SCF (sSCF) that induce CXCL12 release from blood platelets. CXCL12 directly induces mobilization of HSPCs, and hemangiocytes that home to the ischemic tissue to release proangiogenic factors.

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